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Cardiall - 60 caps

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Item # D2165

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CardiAll is designed to optimize healthy heart and blood vessel function.

The cardiovascular system is a complex and sophisticated network. After all, it must work non-stop, 24-hours a day for an average of 77.1 years. Even if we eat a healthy balanced diet, we often do not get the necessary levels of antioxidant nutrients that protect cells from harmful free radicals, neutralizing these molecular marauders.* Antioxidants protect our genetic DNA, cellular membranes, and even the enzyme systems that run our cells' metabolism.* This is why it's critical that we take a quality cardio-protective supplement with key antioxidants every day.

CardiAll is designed to optimize healthy heart and blood vessel function.

Ingredients (per serving)

CoEnzyme Q10 30 mg
L-Carnitine 100 mg
Hawthorn leaf & flower Extract (1.8% Vitexin) 100 mg
Natural Vitamin E (as d-alpha tocopheryl succinate) 200 IU
Folic Acid 800 mcg
Vitamin B6 (as Pyridoxine Hcl) 30 mg
Vitamin B12 (as Cyanocobalamin) 250 mcg
Betaine (as Tri-methyl glycine) 10 mg
Thiamine (Vitamin B1) (as Thiamine Hcl) 3 mg
Riboflavin (B2) 3.4 mg
Niacin (B3)(as Inositol HexaNiacinate) (flush-free) 40 mg
Magnesium (as Magnesium Arginate) 25 mg
Taurine 100 mg
Vitamin A (as natural mixed carotenoids from Dunaliella) 5000 IU
Vitamin C (as Ascorbic Acid) 120 mg
Zinc (as Zinc amino acid chelate) 15 mg
Selenium (as Selenomethionate) 100 mcg
Chromium (as Chromium Niacinate) 200 mcg
Turmeric root extract (95%Curcumin) 10 mg


CoEnzyme Q10: The Miracle Nutrient For The Heart

CoQ10 is a naturally occurring metabolic enzyme which has been heavily researched for cardiovascular health. More than 100 clinical studies at major universities and hospitals have documented the actions of CoQ10. It maintains the strength of the heart muscle more than any other nutrient.* Virtually every cell of the human body contains CoQ10. The mitochondria, the area of cells where energy is produced, contain the most CoQ10. The heart and liver have the greatest amount of CoQ10 because they contain the most mitochondria per cell. Most of us have plenty of CoQ10 in our bodies until around the age of 30. About then, our bodies lose the ability to manufacture it at the same levels, so the natural supply begins to diminish. This important cardiovascular nutrient is thought to be essential for proper heart function.*1 2 It is a powerful antioxidant that protects the body from free radicals.* It has membrane-stabilizing properties shown to prevent the cellular damage that results from normal metabolic processes.* As a coenzyme, this nutrient aids metabolic reactions, such as the complex process of transforming food into ATP, the energy on which the body runs.*

CoQ10 may support the function of the heart by promoting energy production, supporting the ability of the heart to contract, and providing powerful antioxidant protection.* The activity of CoQ10 helps prevent the oxidization of LDL cholesterol, the "bad" kind of cholesterol. Because CoQ10 provides antioxidant protection, it helps prevent this oxidizing process, and in so doing, it helps maintain cholesterol levels that are already within the normal range.* Also, two studies report that CoQ10 promotes a greater ability to exercise.*3 4 And CoQ10 appears to support the heart's function under varying levels of oxygen.*5 The heart is one of the few organs in the body to function continuously without resting; therefore, the heart muscle requires the highest level of energetic support. And any condition that causes a decrease in CoQ10 could influence the energetic capacity of the heart, thus leaving the tissues more susceptible to free radical attack.*6

L-Carnitine: Fuel for the Heart

L-Carnitine is an important amino acid involved in the metabolism and conversion of fatty acids into energy for muscular activity.* While CoQ10 sparks the energy within the cells, L-carnitine is like a shuttle, bringing fuel into heart cells to be burned as energy.* Carnitine has been shown to support healthy heart function,*7 and is beneficial for optimizing endurance, muscle strength and normal weight.*8 9 One six-month double blind trial found that L-carnitine increased their exercise capacity by 26%.10 In animal studies and clinical experience, L-carnitine has been shown to help maintain cholesterol levels already within the normal range.*11

Hawthorn: Protects Blood Vessels

Hawthorn is a particularly rich source of a huge variety of bioflavonoids.* Bioflavonoids are well recognized for their protective effects on blood vessels.* Hawthorn is also an especially significant source of antioxidant anthocyanidins and cardiotonic amines.*12 Hawthorn berries and flowers have a long history of use to help maintain heart health in different cultures.* Due to its great complexity and extraordinary variety of heart-promoting, naturally-occurring compounds, perhaps no other herbal extract has such potential for supporting healthy heart and cardiovascular function as Hawthorn.*13 14 15 Studies suggest that Hawthorn supports cardiovascular health in a variety of ways, including reducing cholesterol oxidation by limiting free radical attack on LDL.*16 In addition, Hawthorn may help maintain blood cholesterol levels already within normal ranges.*

Vitamin E: One of Your Heart's Best Friends

Vitamin E, a fat-soluble essential vitamin, belongs to an elite corps of age-defying nutrients that easily earns blue-ribbon antioxidant status. Study after study has confirmed that vitamin E acts like a loyal bodyguard as it promotes healthy cell membranes.* Vitamin E protects cells from free radical oxidative stress, and therefore helps support the circulatory and cardiovascular system.* According to a new federal survey, 30% of U.S. adults may not be receiving the optimal level of Vitamin E, a condition that can influence the heart. Vitamin E is available in CardiAll in the natural form which is 3-5x more potent than the synthetic form (dl-alpha tocopherol), according to American Journal of Clinical Nutrition 65: 1997.* Vitamin E also supports heart and blood vessel function because of its ability to neutralize the oxidation of LDL cholesterol.* Vitamin E has also been shown to modulate oxidative DNA damage from free radicals following exercise.*17

B-Vitamins, Folic Acid & Betaine: Nutritional Stars for Your Heart

Talk about your overnight sensations...recently, a once obscure B vitamin, Folic Acid (folate), was hailed by mainstream medical researchers as a highly promising nutrient. Folic acid is essential to the formation of red blood cells and aids in protein metabolism, however, prompted by prior positive findings, the National Institutes of Health are funding further research into the vitamin's potential benefits in supporting a healthy cardiovascular system. The U.S. FDA has required that folic acid be added to enriched foods such as breads, flours, pastas, rice, and breakfast cereals. In 1992 the U.S. Public Health Service doubled the RDA for folic acid for women of childbearing age to 400 micrograms a day. The impetus for these changes came from numerous studies linking folic acid levels to healthy heart function, and especially to promoting healthy children at childbirth.*

A major 14-year study which appeared in the Journal of the American Medical Association (JAMA) (Feb. 4, 1998) found that folic acid and B6 could significantly promote healthy heart function.* Evidence from some 20 studies has revealed a previously unrecognized association between a naturally occurring amino acid called homocysteine and heart health. Homocysteine is an amino acid in your blood that can affect the cells lining the blood vessel walls.*18 Folic acid helps maintain homocysteine levels already within the normal range, as do vitamins B6 and B12.*19 20 Vitamin B6 serves a very important role of ensuring that biological processes, including fat and protein metabolism take place, as they should.* Vitamin B12 plays a major role in the metabolism of proteins, fats, and sugars, including the absorption and conversion of folic acid into its active form.* One of most important functions of this vitamin is that it helps to maintain the fatty sheath (myelin) that protects the nerves.*

Less than half of all Americans (12-40%) consume enough folic acid from foods, so leading heart researchers recommend folic acid and B supplements. Of all the vitamins, folic acid absorption is affected most by interaction with common drugs. Antacids, aspirin, alcohol and estrogen replacement drugs all interfere with absorption of folic acid. Numerous studies have shown the powerful effects B vitamins have on homocysteine. Users of vitamin preparations containing these nutrients appeared to experience substantial support for cardiovascular and heart function compared to nonusers.*21 In most cases, vitamin supplementation results in maintaining already normal ranged plasma homocysteine.*22 23 Another important homocysteine-regulating nutrient is Betaine, which is essential in recycling homocysteine back to methionine, and has been shown to help maintain homocysteine levels already in the normal range.*24 25

Vitamin B1 (thiamine) aids in metabolism of carbohydrates, helps maintain the nervous system, skin health and is involved with overall growth.* Vitamin B2 (riboflavin) is important for the maintenance of healthy, supple skin and good vision.* It is one of the essential B vitamins necessary for all sorts of chemical processes inside the body, such as converting food into energy. Inositol HexaNiacinate is a flush-free form of Niacin and is important in promoting a healthy nervous system, skin, and gastrointestinal functioning.*

Magnesium: Unsung Hero of Cardiovascular Health

Magnesium is essential for healthy heart function.* It's crucial to produce the high-energy bonds that drive the energy machinery of your cells. More specifically, magnesium helps maintain proper smooth muscle function in your blood vessels, helps shuttle potassium and sodium into and out of cells maintaining proper membrane balance, and acts to maintain cardiac conduction, heart muscle and vascular membranes.* It serves several crucial roles such as assisting in the nerve and muscular impulses as well as muscular contraction.* Magnesium is necessary for the metabolism of calcium, Vitamin C, phosphorus, sodium, and potassium. Magnesium helps maintain stable heart muscle and vascular membranes. Factors that influence the supply of Magnesium include: chronic emotional and mental stress, long-term use of diuretics, alcohol abuse, prolonged use of antibiotics, malnourishment, and excessive use of some drugs, such as Tagamet or Zantac. It is presented in CardiAll in its well-absorbed aspartate form. Magnesium aspartate is particularly useful in this formula as it helps maintain blood cholesterol levels already within the normal range, provides anti-fatigue effects, and activates cellular metabolism.*26

Taurine: Supports Healthy Heart Function

Taurine is a sulfur-containing, membrane-stabilizing amino acid that is found in high concentrations in muscle tissue. Physicians have used it for supporting healthy heart function.*27 It functions in electrically active tissues such as the heart and brain to help maintain stable cell membranes.* It also has functions in the blood vessels and appears to have some antioxidant and detoxifying activity.* Taurine aids the movement of potassium, sodium, calcium, and magnesium in and out of cells and thus helps support healthy nerve function.* It comprises over 50% of the total free amino acid pool of the heart, and has been shown in some studies to help maintain blood pressure and cholesterol levels already within the normal ranges.*28 29

Carotenoids: Health Promoting Antioxidants

Antioxidant vitamins such as Beta-carotene have been hailed as lifesavers for their ability to help protect our health and provide support for a healthy body. They neutralize free radicals (the oxygen molecules that damage our body's cells). Carotenoids are acknowledged by the leading heart health association in America to support healthy heart and blood vessel function.*30 Beta carotene is an extremely important player in promoting heart health. More than 200 studies have confirmed that foods rich in flavonoids, carotenoids and other antioxidants provide support for a healthy cardiovascular function.* Consumption of fresh fruits and vegetables has long been associated with promoting heart and eye health. If you eat at least five to nine servings of fresh organic fruits and vegetables per day, you will, on average, take in enough carotenoids to meet your body's needs. But it can be a challenge to consume this many servings daily. That's why it makes sense to take out the additional insurance in supplements. Each serving of CardiAll contains 5000 IU of natural mixed carotenoids from Dunaliella.

Vitamin C: Still an All-Around Antioxidant Champ

Vitamin C is one of the best-known antioxidants, first made famous by the work of Linus Pauling, two-time Nobel laureate who pioneered much of the research on its benefits. More research has been done on vitamin C than any other nutrient. In addition to its wide-ranging antioxidant talents, vitamin C promotes heart, immune and bone and joint health.* It also promotes healthy blood-vessel linings and helps support already normal ranged levels of Lp(a), a major factor in cardio health, while supporting the production of glutathione, another potent antioxidant.*

Key Minerals: Zinc, Selenium, & Chromium for Health

Zinc is a trace mineral present in and indispensable to all forms of life. It is essential for growth, pregnancy, and transmission of our genetic material.* Zinc is required as an enzyme component in the eyes, liver, kidneys, muscles, skin, testes, and other organs. The highest concentrations of zinc are in bones, the prostate gland, and the eyes. Selenium is a trace mineral that is a structural element of the enzyme that protects glutathionine, which serves as part of the body's internal defense against free radical damage. Selenium works hand in hand with Vitamins C, E, and beta-carotene as an antioxidant defense. Chromium is a trace mineral that is necessary for the proper functioning of insulin. Insulin plays a major role in the metabolism of sugar and is involved in the body's use of protein and fat.

Turmeric: A Potent Spice for the Heart

Turmeric is an ancient spice dating back to the time of the Egyptian pharaohs. It is also a traditional remedy in Ayurvedic medicine, an ancient Indian health system that dates back over 5,000 years. It has also been highly prized by Indo-Europeans, and today is generating a lot of attention in the scientific community because of its many health-protective benefits. New research shows this zesty spice, which puts the zing in curry sauces, may provide powerful support for healthy heart and blood vessel function.* The key appears to lie in a compound called Curcumin, which is found in turmeric. Curcumin provides broad-spectrum effects throughout the body. In addition to being a potent antioxidant, Curcumin suppresses an enzyme which is important for good health and overall comfort.* Turmeric's protective effects on the cardiovascular system include helping to maintain cholesterol and triglyceride levels that are already within the normal range, decreasing susceptibility of low density lipoprotein (LDL) to lipid peroxidation,31 and promoting already normal platelet aggregation.*32 Curcumin may also help support and maintain healthy joint function, flexibility, and mobility.*33 34 35 36 37

REFERENCES

1. Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10: a long-term multicenter randomized study. Clin Invest 1993;71:S134'36. 2. Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy. Drug Exptl Clin Res 1985;11:581'93. 3. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance. Am J Cardiol 1985;56:247. 4. Mortensen SA. Perspectives on therapy with coenzyme Q10 (ubiquinone). Clin Invest 1993;71:s116'23. 5. Tanaka J, Tominaga R, Yoshitoshi M, et al. Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement. Ann Thorac Surg 1982;33:14551. 6. Molecular Aspects of Medicine, 1994, 15 Supplement 7. Dipalma JR. Carnitine deficiency. Am Family Phys 1988;38:243-51. 8. Giamberardino MA et al. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996;17:320-4. 9. Kendler BS. Carnitine: an overview of its role in preventive medicine. Prev Med 1986;15:373-90. 10. Mancini M, Rengo F, Lingetti M, Sorrentino GP, Nolfe G. Controlled study on the therapeutic efficacy of propionyl-L-carnitine. Arzneimittelforschung 1992;42:1101'4. 11. Fujita T; Ando K; et al: Effects of increased adrenomedullary activity and taurine in young patients with borderline hypertension. Circulation, 75(3):525-32 1987 Mar 12. Cook N.C. & Samman S. 'Flavonoids-Chemistry, metabolism, cardioprotective effects, and dietary sources' Nutritional Biochemistry 1996, 7:66-76. 13. Bahorun T, Trotin F, et al. Antioxidant activities of Crataegus monogyna extracts. Planta Med 1994; 60:323-8. 14. Rewerski VW, Piechoscki T, et al. Some pharmacological properties of oligomeric procyanidin isolated from hawthorn (Crataegus oxyacantha). Arzneim-Forsch Drug Res 1967; 17:490-1. 15. Weikl A, Noh HS. The influence of Crataegus on global cardiac insufficiency. Herz Gefabe 1993; 11:516-24. 16. Rajendran S et al. Effects of tincture of Crataegus on the LDL receptor activity of hepatic plasma membrane of rats fed an atherogenic diet. Atherosclerosis 1996;123:235-241. 17. Mutation Research 346:1995 18. Circulation 97, Feb.10, 1998 19. American Journal of Clinical Nutrition 1998:68 20. Lancet 346, 1995 21. Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrom LE, Ueland PM, Palma-Reis RJ, et al. Plasma homocysteine. The European Concerted Action Project. JAMA. 1997; 277(22):1775-81. 22. Ubbink JB, Vermaak WJH, van der Merwe A, Becker PJ, Delport R, Potgieter HC. Vitamin requirements for the treatment of hyperhomocystinemia in humans. J Nutr. 1994; 124:1927-33. 23. Swift ME, Schultz TD. Relationship of vitamins B6 and B12 to homocysteine levels. Nutr Rep Int. 1986; 34:1-14. 24. Betaine for Homocystinuria. The Medical Letter. 1997; 39(993):12. 25. Boers GHJ. Hyperhomocystinemia: A Newly Recognized Risk Factor For Vascular Disease. Netherlands Journal of Medicine. 1994; 45:34-41. 26. Gissen A.S. "Magnesium and Health" Nutritional News July, 1993. 27. Bousquet P, Feldman J, Bloch R, Schwartz J. Central cardiovascular effects of taurine: comparison with homotaurine and muscimol. J Pharmacol Exp Ther 1981;219:213-218. 28. Fujita T, Ando K, Noda H, et al. Effects of increased adrenomedullary activity and taurine. Circulation 1987;75:525'32. 29. Huxtable RJ and Sebring LA. Cardiovascular actions of taurine. In: Kuriyama K, Huxtable R, Iwata H (eds.), Sulfur Amino Acids: Biochemical and Clinical Aspects. New York:Alan R. Liss;1983:5-37. 30. Better Nutrition, October 1997, 59:10, 48( 5). 31. Ramirez-Tortosa MC, Mesa MD, Aguilera MC, et al. Oral administration of a turmeric extract inhibits LDL oxidation in rabbits. Atherosclerosis 1999;147:371-378. 32. Srivastava R, Puri V, Srimal RC, Dhawan BN. Effect of curcumin on platelet aggregation. Arzneim Forsch 1986;36:715-717. 33. Brouet I, Ohshima H. Curcumin inhibits induction of nitric oxide synthetase in activated macrophages. Biochem Biophys Res Commun 1995;206:533-540. 34. Chandra D, Gupta S. Arthritic activity of volatile oil of Curcuma longa (Haldi). Ind J Med Res 1972;60:138-142. 35. Arora R, Basu N, Kapoor V, et al. Studies on Curcuma longa (turmeric). Ind J Med Res 1971;59:1289-1295. 36. Mukhopadhyay A, Basu N, Ghatak N, et al. Irritant activities of curcumin analogues in rats. Agents Actions 1982;12:508-515. 37. Srivastava R. Inhibition of neutrophil response by curcumin. Agents Actions *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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